Xiaoying Cai

This paper develops a CD40 agonistic-monovalent streptavidin fusion antibody that delivers neoantigen peptides to APCs, enhancing cancer vaccine efficacy and tumor regression in mice.

The paper describes a protein fold switch in a bactericidal nanomachine that enables membrane puncture and bactericidal activity.

This paper develops a method to obtain correlative multiscale 3D images of mouse tumors using sequential light sheet and confocal fluorescence microscopy, enabling spatial analysis of immune responses and metastasis.

This paper introduces an LED photobleaching method to enhance 3D immunofluorescence microscopy multiplexity for tumor microenvironment analysis, achieving 8-plex imaging.