Amy L. Ryan

This study defines a functional correction threshold for gene therapies in PCD by analyzing how mixed populations of mutant and wild-type ciliated cells affect mucociliary transport.

This paper introduces dECM-AoAO organoids that better recapitulate native airway epithelial composition and function compared to ECM-free models.

The paper integrates proteomic and transcriptomic data from a small cohort of COVID-19 patients to identify key variables correlated with disease severity.

The paper compares mucociliary clearance in human and rat airways, finding species-specific structural differences that affect clearance effectiveness and identifying limitations of lab-grown cultures.

This study shows that different culture media significantly alter the inflammatory phenotype and functional properties of human tracheo-bronchial basal stem cells.

The paper uses 3D spheroids and spatial transcriptomics to identify LAMFs and LECs as key contributors to LAM, with bFGF and VEGF-A as potential therapeutic targets.

This study shows engineered hydrogels improve lung progenitor cell differentiation from iPSCs compared to Matrigel, offering a more defined and controllable method for clinical applications.

The paper identifies TRIP13 as a mediator of AT2 cell dysfunction in IPF through integrated transcriptomic and epigenomic analysis and shows TRIP13 inhibition prevents mesenchymal gene signature acquisition.

The paper identifies RBL2 as a repressor of Multicilin's transcriptional activity, showing it inhibits multiciliogenesis in airway epithelial cells.

This study identifies proteomic biomarkers associated with varying severities of COVID-19, highlighting proteins like mesothelin and immune-related markers linked to disease progression.

This study identifies key epigenetic states and transcription factor networks in human alveolar epithelial differentiation, revealing dynamic enhancer changes and regulatory interactions critical for distal lung identity.