Christoph Heuser-Loy

SCITRAM predicts master transcription factors from single-cell transcriptomics data by reconstructing gene regulatory networks and modeling transcriptional cascades.

This study identifies ZC3H12C as a target for improving T cell persistence and antitumor function in adoptive T cell therapy by disrupting its expression.

This study shows that inhibiting LSD1 enhances CD8+ T cell function in adoptive T cell therapy, leading to improved antitumor immunity and synergistic effects with anti-PDL1 therapy.