Author
University of Eastern FinlandORCID 0000-0003-1539-2142Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Eleni Georgiou, Tuomo Laitinen, Antti Poso…·Christopher R. M. Asquith
This study identifies and optimizes a submicromolar PKN3 inhibitor, 6e (URS03-06), for cellular biology research.
Marwah Karim, Manjari Mishra, Chieh‐Wen Lo…·Shirit Einav
RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.
Christopher R. M. Asquith, Michael P. East, Tuomo Laitinen…·Gary L. Johnson
The paper identifies and optimizes narrow-spectrum TLK2 inhibitors using QSAR analysis and structural studies.
Ashik Jawahar Deen, Simone Adinolfi, Jouni Härkönen…·Anna–Liisa Levonen
This study shows that KEAP1 mutations in lung cancer activate TRAF2-NFκB signaling, enhancing cell survival by preventing apoptosis.
Christopher R. M. Asquith, James M. Bennett, Lianyong Su…·William J. Zuercher
The paper develops SGC-GAK-1 as an orally active in vivo probe for GAK by using cytochrome P450 inhibition to improve its metabolic stability and plasma exposure.
Christopher R. M. Asquith, Kaitlyn A. Maffuid, Tuomo Laitinen…·William J. Zuercher
The paper designs and evaluates novel 4-anilinoquinolines and quinazolines as EGFR inhibitors, identifying a potent compound for lung cancer and chordoma treatment.