Yansong Miao

This study engineers the Arabidopsis FLS2 receptor to control its oligomerization, showing that dimerization enhances immune responses while tetramerization impairs receptor turnover and weakens sustained signaling.

The paper analyzes phase-separating proteins across 1,106 species to reconstruct the evolutionary history of protein condensation and identifies phase separation-regulated signaling hubs.

This study identifies MoSpa2's role in organizing actin nucleation centers in Magnaporthe oryzae through phase separation, supporting polarized growth and host infection.

This study identifies ARHGAP12 as a regulator of the paracellular leak pathway by suppressing F-actin assembly at tight junctions without affecting ion flux.

The paper demonstrates that membrane curvature catalyzes actin nucleation through the condensation and activation of N-WASP by FBP17, revealing a curvature-guided mechanism for actin remodeling.

MolPhase predicts protein phase separation using physicochemical features and experimental data, showing T3Es undergo homotypic phase separation in vitro and in vivo.

This study investigates the collective dynamics of formin and microtubule networks, revealing FHDC1's role in regulating actin wave nucleation and its crosstalk with microtubules.