Saif Dababneh

This study compares transcriptional heterogeneity in the cardiac conduction system across species and developmental stages using single-cell and spatial transcriptomic data.

This study uses hiPSC-derived cardiomyocytes to model CRDS, showing that programmed electrical stimulation induces arrhythmias through EADs and re-entry, which can be suppressed by flecainide.

This study shows that intermittent fasting improves systemic metabolism regardless of ketogenesis but has sex-specific hepatic benefits requiring ketogenesis in mice.

This study investigates how metabolic maturation affects molecular and metabolic states in hiPSC-derived cardiomyocytes with TNNT2-linked hypertrophic cardiomyopathy, revealing variant-specific disruptions in metabolic pathways and gene regulation.

This study shows that passaging hiPSC-derived cardiac fibroblasts activates them to myofibroblasts, involving TGFβ1, Hippo signaling, and mitochondrial metabolism changes.