Ramon I. Klein Geltink

The paper shows beta cells transfer mitochondria to islet macrophages, enhancing their protein synthesis and altering gene expression, suggesting a new communication mechanism in islet homeostasis.

This paper develops and validates versatile electroporation protocols for efficient CRISPR-RNP delivery in multiple primary mouse hematopoietic cells, achieving high gene knockout efficiency with minimal cell damage.

This study identifies immunometabolic factors in CD19 CAR T cells that predict long-term response in B-ALL patients and suggests mTOR inhibition as a strategy to enhance anti-tumor activity.

This study investigates how metabolic maturation affects molecular and metabolic states in hiPSC-derived cardiomyocytes with TNNT2-linked hypertrophic cardiomyopathy, revealing variant-specific disruptions in metabolic pathways and gene regulation.

This study shows CD8+ T cells adapt to nutrient stress by reconfiguring gene-regulatory and metabolic networks, enabling functional resilience and anti-tumor immunity.

This study shows that passaging hiPSC-derived cardiac fibroblasts activates them to myofibroblasts, involving TGFβ1, Hippo signaling, and mitochondrial metabolism changes.

LaRCH, a tree-structured topic model, improves clustering of single-cell RNA-seq data and reveals transcriptomic differences in SLE by capturing hierarchical immune cell relationships.

This paper introduces CloneSelect, a multi-kingdom genetic barcoding system that enables precise isolation of target clones using CRISPR base editing to trigger reporter gene expression.