Florian Siegerist

This study investigates alternative splicing and miRNA regulation in a zebrafish FSGS model, identifying key splicing events and miRNAs associated with disease progression.

This study identifies MAGI2 as a conserved biomarker for podocyte injury, showing its downregulation in glomerular diseases and differential expression in primary vs secondary FSGS.

This study investigates ILDR2's role in glomerulopathies, finding it upregulated in disease models and suggesting a protective effect against glomerular damage.

This paper introduces a workflow for highly multiplexed immunofluorescence compatible with super-resolution microscopy, validated using a mouse model and human dataset.

This study introduces Nifurpirinol as a more efficient prodrug for inducing FSGS-like glomerular injury in zebrafish larvae, suitable for high-content drug screening.

This paper demonstrates that synthetic CTNS mRNA therapy can restore cystinosin function and reduce cystine accumulation in kidney cells and zebrafish models of cystinosis.

This study evaluates miRNA reference genes in zebrafish across strains, developmental stages, and kidney disease models, identifying dre-miR-92b-3p as the most stable reference gene.