Author

Jiangchuan Shen

Duke UniversityORCID 0000-0003-1699-564XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:yeast· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Hengyao NiuiD· 2 shared Zhitong Feng· 2 shared David G. Nickens· 1 shared Giovanni González-GutiérreziD· 1 shared Matthew L. BochmaniD· 1 shared Quan WangiD· 1 shared Robert H Simmons· 1 shared Spencer J GrayiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Hengyao NiuORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 2, 2025

Dual DNA-binding capability of Cdc13 coordinates with Ku to safeguard telomere integrity

Zhitong Feng, Jiangchuan Shen, Yuxi Li…·Hengyao Niu

This study shows that Cdc13's dual DNA-binding capability coordinates with Ku to protect telomeres, and mutations in this function lead to metabolic reprogramming and increased fitness in yeast.

DOI 10.1101/2025.09.02.671137

yeastgenetic perturbation / CRISPR

𝕏 PostBluesky

BiochemistryNucleic Acids ResearchPeer-reviewedApr 1, 2024

Cdc13 exhibits dynamic DNA strand exchange in the presence of telomeric DNA

David G. Nickens, Zhitong Feng, Jiangchuan Shen…·Matthew L. Bochman

This study shows that Cdc13 can dynamically exchange DNA strands in the presence of telomeric DNA, revealing a mechanism for its movement at telomeres.

5 citations

yeastDNA methylation

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