Author

Raphael Trenker

University of California, San FranciscoORCID 0000-0003-1748-0517Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Kliment A. VerbaiD· 2 shared Natalia JuraiD· 2 shared Advait SubramanianiD· 1 shared Alan D. FrankeliD· 1 shared Alice Mac KainiD· 1 shared Alicia RichardsiD· 1 shared Ashleigh S DaveyiD· 1 shared Assaf ElazariD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

Kliment A. VerbaORCID

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3 papers

Recent·Most cited

BiochemistryeLifePeer-reviewedNov 24, 2023

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

Raphael Trenker, Devan C. Diwanji, Tanner Bingham…·Natalia Jura

This study reports cryo-EM structures of HER2/HER4 heterodimers and HER4 homodimers bound to different ligands, revealing structural dynamics and glycan contributions to receptor activation.

28 citations

humanstructural biology

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Synthetic BiologyeLifePeer-reviewedApr 19, 2022

De novo designed transmembrane domains tune engineered receptor functions

Assaf Elazar, Nicholas J. Chandler, Ashleigh S Davey…·Sarel Jacob Fleishman

The paper designs transmembrane domains to control receptor function, showing that oligomeric state affects CAR T cell activity and cytokine release.

58 citationstop 3%

humanproteomics

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Systems BiologyNaturePeer-reviewedApr 30, 2020

✦ In-depth digest

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou…·Natalia Jura

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.

4,405 citationstop 1%

humanvirus

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