Caroline A. Lewis

This study uses a human liver microphysiological system to investigate how insulin, glucose, and free fatty acids contribute to hepatic insulin resistance and its reversibility.

This study shows seipin is essential for recruiting Perilipin-1 to lipid droplets in human adipocytes, maintaining adipocyte identity and preventing de-differentiation.

This study identifies HSD17B13 as a dual metabolic and profibrotic effector that drives TGFb-1-dependent activation of hepatic stellate cells, linking lipid metabolism to fibrogenesis in MASH.

The paper constructs a multi-tissue lysosomal metabolite atlas in mice, revealing age-related accumulation of glycerophosphodiesters and cystine, linked to lysosomal storage disorders, and shows caloric restriction mitigates these changes in some tissues.

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

The paper investigates the functional specialization of SAM synthases in C. elegans, showing that SAMS-1 affects mitochondrial function and stress survival through phosphatidylcholine, while SAMS-4 is critical for methylation reactions.

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

The paper introduces MITO-Tag Mice to isolate mitochondria from specific cell types in vivo and identifies mitochondrial metabolite changes during fasting and refeeding in hepatocytes.