Juan Iovanna

This study shows that GATA4 loss in Kras-mutant mice leads to PDAC without canonical precursor lesions, identifying a new lesion type and revealing GATA4's role in inflammatory programs.

This study shows that KRAS inhibition can reverse chemotherapy resistance in PDAC by targeting therapy-induced senescence-like cells, with ERK pathway involvement.

This study shows NUPR1 inhibition worsens oxidative stress, mitochondrial dysfunction, and metabolic imbalance in COPD, linking it to ferroptosis and disease progression.

The paper develops an immunohistochemical panel to assess intra- and inter-tumoral heterogeneity in PDAC, identifying four distinct phenotypes with clinical implications.

SMAP improves sequencing analysis of xenografts by accurately mapping reads to both host and graft genomes and enhancing fusion transcript detection.