Scott B. Biering

This study shows that flavivirus NS1 promotes virus dissemination by causing endothelial dysfunction, both in vitro and in vivo, and suggests NS1 as a therapeutic target.

This study identifies ephrin B1 as a host factor mediating dengue virus NS1-induced endothelial barrier dysfunction and shows EFNB1-Fc fusion proteins can block this effect.

This study evaluates cyclodextrins' ability to reduce endothelial dysfunction and antiviral activity against DENV and SARS-CoV-2 in vitro and in vivo.

This study identifies GP38 as a viral toxin causing vascular leak and shows that specific GP38-targeting antibodies block this effect in vitro and in vivo.

This study shows DENV NS1 activates inflammasomes in macrophages, leading to IL-1β release without pyroptosis, and that this pathway is protective against DENV infection.

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.