Selvakumar Subbian

This study shows that combining sulforaphane and deferoxamine reduces iron accumulation and inflammation in the hippocampus after neonatal IVH, protecting against neuronal death and promoting recovery.

This study shows that malnourishment and microbiome changes enhance the efficacy of a recombinant BCG TB vaccine in mice, linking diet, microbiota, and immune responses to TB protection.

This study shows that sulforaphane and deferoxamine combination therapy reduces inflammation and iron toxicity in neonatal intraventricular hemorrhage by modulating microglia and gene expression.

This study identifies differences in inflammasome activation pathways that correlate with varying outcomes of Mycobacterium tuberculosis infection.

This study performs proteomic analysis of Mycobacterium tuberculosis lacking Rv0148, identifying changes in protein expression and pathways related to stress response, cell wall, and metabolism.

This study shows that CD8+ T cells prevent reactivation of latent Mtb infection after immunosuppression, while B cells are not required for this protection.

The paper uses mathematical modeling to show that Mycobacterium tuberculosis replication in rabbit lungs is heterogeneous, with subpopulations exhibiting different growth kinetics.

This study shows that fatty acid metabolism in neutrophils worsens lung damage and bacterial replication in tuberculosis by promoting inflammation and neutrophil recruitment.