Anthony E. Jones

This study shows Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling by providing a weak TLR4 signal.

This study shows that UCP1-deficient mice adapt to cold by increasing mitochondrial calcium uptake via MCU, enhancing thermogenesis without UCP1.

This study shows the malate aspartate shuttle supports lipid mobilization in brown adipocytes by regulating lipid homeostasis and thermogenesis.

This study shows IGF2BP3 regulates RNA methylation by altering cellular metabolism to increase SAM production, enhancing m6A modifications and gene expression in leukemia.

This study shows that reduced oxidative phosphorylation is not required for pro-inflammatory macrophage activation, challenging the conventional model of mitochondrial reprogramming.

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.