Kerstin Göpfrich

This study compares three lipid force fields for membrane remodeling using molecular dynamics simulations, finding differences in pore formation and stability under enhanced sampling methods.

This paper introduces alphaKL, a new RNA connector that enables edge-to-edge assembly of RNA nanostructures, expanding their structural design space.

This paper demonstrates the ability to track nanometric movements of fluorophores using MINFLUX microscopy, showing sub-10 nm distance changes can be detected within milliseconds.

This paper introduces a buoyancy-driven method to sort synthetic cells based on nanopore activity without labels or imaging.

This paper demonstrates genetically encoded RNA droplets that can dissolve, segregate, and regrow through ribozyme catalysis, establishing a minimal cycle for synthetic life.

This paper compares volume and surface methods for microparticle traction force microscopy through simulations and experiments, finding the surface method more accurate but with reduced performance at high noise levels.

This paper introduces an automated image-based cell sorting method that enriches activated T cells from blood with high throughput and label-free morphology-based classification.

PyFuRNAce provides a user-friendly platform for designing RNA origami nanostructures, integrating motif definition, blueprint design, sequence generation, and primer selection into a single tool.

This paper introduces DNA-based hydrogel microparticles with tunable mechanical properties for 3D cellular systems, showing they can be remodeled by fibroblast spheroids based on their stiffness.

This paper introduces RNA origami cytoskeletons in synthetic cells, demonstrating their self-assembly and functional expression in lipid vesicles.

The paper introduces PRISM-MS, a method for fast single-cell MALDI imaging of low-mass metabolites, and demonstrates its application in analyzing metabolome changes in LPS-stimulated microglial cells.

This paper introduces DNA microbeads to control morphogen release in organoids, enabling spatio-temporal regulation of development and improving tissue mimicry.

The paper presents a platform for minimal-invasive 3D laser printing of microimplants in vivo using synthetic polymer inks, demonstrating biological responses in teleost fish and fruit fly embryos.

The paper uses DNA-nanomotifs to mimic transcriptional cluster dispersal in stem cells, showing that amphiphilic effects control droplet size and shape.