Lonneke Vervelde

This study identifies a virulence mechanism in low pathogenic avian influenza viruses where neuraminidase recruits plasminogen to cleave hemagglutinin, enhancing pathogenicity.

This study investigates the role of IL10 in avian mucosal immunity by generating IL10-deficient chickens, showing altered microbiome composition and enhanced pathogen clearance with increased inflammation.

This study reinstates RIG-I and RNF135 in chickens to investigate their role in avian influenza response, finding that their expression exacerbates inflammation and mortality without affecting viral replication.

This study compares the caecal microbiota of XCR1 knockout chickens with and without IBV vaccination, finding that vaccination, not XCR1 absence, significantly alters microbiota composition.

This study compares innate immune responses in 2D and 3D chicken enteroids infected with Salmonella Typhimurium, showing that 3D models better mimic in vivo responses due to the presence of lamina propria cells.

This study identifies TIM4-expressing mononuclear phagocytes in chickens, distinguishing phagocytic Kupffer cells from non-phagocytic DC-like cells using CSF1R reporters.