Author
Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0003-2259-9002Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Jun Zhi Xu, Ruoyi Qiu, Alexander M. Garces…·Brian K. Kobilka
This study uses single-molecule imaging to show how agonist-specific dynamics in structured and disordered regions of the 2AAR regulate signaling and function.
Lior Peri, Donna Matzov, Dominic R. Huxley…·Moran Shalev-Benami
The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.
Annika Ullrich, Johannes Schneider, João M. Braz…·Peter Gmeiner
The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.
Fabrizio Fierro, Lior Peri, Harald Hübner…·Masha Y. Niv
The paper discovers new ligands for the promiscuous TAS2R14 bitter taste receptor using a mixed experimental and computational approach, identifying 10 antagonists and 200 agonists.