Harald Hübner

This study systematically evaluates the effectiveness of random small perturbations in ligand optimization, finding 11.2% of analogs improved potency by ≥10-fold but often had worse pharmacokinetics.

This study uses single-molecule imaging to show how agonist-specific dynamics in structured and disordered regions of the 2AAR regulate signaling and function.

This study identifies structural features determining G protein coupling specificity at a class A GPCR using a Gi-biased agonist.

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

The paper discovers new ligands for the promiscuous TAS2R14 bitter taste receptor using a mixed experimental and computational approach, identifying 10 antagonists and 200 agonists.