Matthew Jenner

This study characterizes SidG, a GNAT enzyme in Aspergillus fumigatus, revealing its iterative acetylation mechanism for siderophore biosynthesis.

The paper identifies a novel subunit docking mechanism in depsipeptide HDAC inhibitor biosynthesis using gene proximity searching and experimental validation.

Random forest predictors PARAS and PARASECT, trained on 3,653 curated adenylation domains, outperform earlier NRPS substrate predictors and correctly assigned L-Trp to an unusual tryptopeptin synthetase domain.

The paper characterizes the AT:ACP interface in a fungal polyketide synthase using mutagenesis, mass spectrometry, and simulations to reveal structural and functional insights.

This study investigates the acyl group selection mechanism in fungal hrPKS condensing regions through in vitro reconstitution and mass spectrometry, revealing substrate recycling and kinetic parameters as key factors.

The paper solves the structure of an acyl hydrolase (AH) domain and investigates its mechanism for hydrolyzing short-chain thioesters on acyl carrier protein (ACP) domains in trans-AT PKSs.

The paper investigates how structural diversity in polyketide antibiotics arises through differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases.