Gregory L. Challis

The paper identifies a novel subunit docking mechanism in depsipeptide HDAC inhibitor biosynthesis using gene proximity searching and experimental validation.

This paper develops an esterase-mediated strategy to generate unstable substrates for EpnF, revealing its broad substrate tolerance and catalytic mechanism for epoxyketone synthesis.

The paper reveals a cryptic amidation mechanism in gladiolin biosynthesis involving a trans-acyltransferase, ACP, and asparagine synthetase homolog.

Random forest predictors PARAS and PARASECT, trained on 3,653 curated adenylation domains, outperform earlier NRPS substrate predictors and correctly assigned L-Trp to an unusual tryptopeptin synthetase domain.

This study identifies key biosynthetic enzymes in methylenomycin production and discovers more potent intermediates active against drug-resistant Gram-positive bacteria.

This paper identifies and characterizes pellemicin, a spirotetronate with antiviral activity against influenza A and B viruses by inhibiting clathrin-mediated endocytosis.

The paper identifies a novel polychlorinated compound produced by Burkholderia oklahomensis and proposes its biosynthetic pathway.

The paper identifies a novel acetylated derivative of piericidin A1 from Kitasatospora sp. A2-31 that shows 100% mortality against the cacao mirid bug.

The paper investigates nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs, showing its importance for bioactivity and revealing the enzymatic mechanisms involved.

The paper investigates how structural diversity in polyketide antibiotics arises through differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases.

The paper uses metagenomic domain substitution to generate novel non-ribosomal peptides by screening over 1,000 domains in a pyoverdine NRPS, resulting in 16 distinct products.

clusterTools identifies putative biosynthetic gene clusters by querying functional elements in genomic data.