Xinyun Jian

The paper identifies a novel subunit docking mechanism in depsipeptide HDAC inhibitor biosynthesis using gene proximity searching and experimental validation.

The paper investigates nitrogen deletion in the biosynthesis of HDAC-targeting anticancer drugs, showing its importance for bioactivity and revealing the enzymatic mechanisms involved.

This study creates novel hybrid aminoglycoside antibiotics by swapping glycosyltransferases between gentamicin and kanamycin producers, resulting in compounds with potent activity and reduced ototoxicity.

The paper investigates how structural diversity in polyketide antibiotics arises through differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases.