Simona M. Miron

This study identifies and characterizes P-motifs in BRCA2 and RAD54B that bind to DMC1 filaments through stable and transient interactions, revealing structural insights into their roles in meiotic recombination.

The paper identifies a non-canonical BRCA2 variant in moss that promotes homologous recombination and binds ssDNA without a canonical DNA binding domain.

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

This paper explains how BRCA2's FxxA and FxPP motifs bind to DMC1 and RAD51 via distinct interfaces, stabilizing recombinase filaments and explaining functional differences between these proteins.

This paper investigates the role of BRCA2's meiotic domain in meiotic homologous recombination and proposes a model of chromosome pairing through tensed DNA tethers.

This paper identifies a cryptic BRCA2 repeated motif that binds to HSF2BP oligomers but does not affect meiotic recombination.