Author
Shili Lin
The Ohio State UniversityORCID 0000-0003-2467-4491Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2021-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 14 mutual co-author links8 papers
Recent·Most cited
- BioinformaticsPLoS ONEPeer-reviewed
Can Random Walking on a Hi-C Contact Matrix Lead to Data Quality Improvement? An Assessment
This study evaluates random walk methods for improving Hi-C data quality, finding no significant benefit for TAD identification despite parameter tuning challenges.
1 citation - GenomicsbioRxivPreprint
Novel Spatial-Structural-Zero-Aware Dissimilarity Measures for Subtype Discovery Using Single Cell Hi-C Data
Yongqi Liu, Victor X. Jin, Shili Lin
This study introduces szKendall, a dissimilarity measure for scHi-C data that accounts for structural zeros, improving cell clustering performance.
DOI 10.1101/2025.07.23.666407 - BioinformaticsBMC BioinformaticsPeer-reviewed
scHiCSRS: A Self-Representation Smoothing Method with Gaussian Mixture Model for Imputing single-cell Hi-C Data
Qing Sheng Xie, Wang Meng, Shili Lin
scHiCSRS improves scHi-C data quality by distinguishing structural zeros from dropouts, leading to more accurate clustering in downstream analysis.
1 citation - BioinformaticsNature CommunicationsPeer-reviewed
Integration of scHi-C and scRNA-seq data defines distinct 3D-regulated and biological-context dependent cell subpopulations
Yufan Zhou, Li Tian, Lavanya Choppavarapu…·Victor X. Jin
The paper integrates scHi-C and scRNA-seq data to identify 3D-regulated cell subpopulations in breast cancer, revealing new chromatin structures and biological contexts.
- GeneticsPLoS Computational BiologyPeer-reviewed
HiCImpute: A Bayesian Hierarchical Model for Identifying Structural Zeros and Enhancing Single Cell Hi-C Data.
Qing Sheng Xie, Chenggong Han, Victor X. Jin, Shili Lin
HiCImpute identifies structural zeros in scHi-C data and improves imputation, leading to more accurate clustering and subtype discovery in neuronal cells.
12 citations - Systems BiologybioRxivPreprint
Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability
Wolfgang Sadée, Ian H. Cheeseman, Audrey C. Papp…·Larry S. Schlesinger
The paper examines inter-individual variability in human alveolar macrophage responses to Mycobacterium tuberculosis by analyzing gene and protein expression over time.
2 citations - GeneticsbioRxivPreprint
Bayestrat: Population Stratification Correction Using Bayesian Shrinkage Prior for Genetic Association Studies
Zilu Liu, Asuman Turkmen, Shili Lin
Bayestrat improves population stratification correction in genetic association studies by using Bayesian shrinkage priors, reducing type I error while increasing power in simulations and real datasets.
DOI 10.1101/2021.03.23.436705