Xujia Zhou

This study uses proteomic profiling to identify age-related changes in transporter proteins in human brain microvessels, revealing alterations in BBB permeability and drug disposition.

This study shows that CRISPR activation can rescue electrophysiological deficits in SCN2A haploinsufficiency by increasing the expression of the remaining functional allele in mice and human neurons.

This study identifies SLC22A10 as a nonfunctional pseudogene in humans due to a missense mutation, while great ape orthologs retain functional uptake of estradiol-17β-glucuronide.

The paper identifies impaired cerebellar plasticity as a mechanism underlying hypersensitized sensory reflexes in SCN2A-associated ASD, showing that increasing Scn2a expression rescues VOR plasticity in mice.