Yan Wu

This study shows that targeting LRP8 for degradation reduces GPX4 levels, sensitizing cancer cells to ferroptosis by disrupting selenium-dependent antioxidant defenses.

The paper introduces improved bioluminescent calcium sensors and opsin variants for non-invasive imaging and synaptic transmission in C. elegans.

This paper introduces MIDAS, a method to rapidly optimize protein function in mammalian cells, demonstrating its effectiveness in improving a neurotransmitter indicator.

The paper designs a new class of protease inhibitors targeting coronavirus Mpro, identifying ML1000 as a potent inhibitor with low-nanomolar affinity and antiviral activity.