Author

Madeleine T. Shackleford

University of Colorado AnschutzORCID 0000-0003-2599-1747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Camryn S. NesibaiD· 2 shared Carmen E. RowlandiD· 2 shared Joseph L. SottnikiD· 2 shared Maggie MusickiD· 2 shared Matthew J. SikoraiD· 2 shared Amanda L. RicheriD· 1 shared Andrew E. GoodspeediD· 1 shared Andy NelsoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Camryn S. NesibaORCID

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2 papers

Recent·Most cited

Cancer BiologyPLoS GeneticsPeer-reviewedOct 27, 2026

CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells

Maggie Musick, Chinasa A Ufondu, Carmen E. Rowland…·Matthew J. Sikora

This study shows that CDH1 loss in human mammary epithelial cells remodels gene expression and lineage identity toward a luminal progenitor-like state, contributing to ILC oncogenesis.

4 citationstop 2%

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyCancer ResearchPeer-reviewedJan 9, 2026

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba…·Matthew J. Sikora

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

7 citationstop 2%

humanbulk RNA-seq

𝕏 PostBluesky