Xiaonan Liu

This study uses chromosome-level genomics and cross-species enzyme screening to enhance bakuchiol production in Yarrowia lipolytica through metabolic engineering.

This study identifies FoTO1 as an epoxide isomerase that facilitates the productive rearrangement of taxadiene-4(5)-epoxide in paclitaxel biosynthesis.

The paper designs artificial cytochrome P450 enzymes by applying a 'three-point fixation' model derived from structural and evolutionary analysis, resulting in enzymes with enhanced catalytic activity.