Dominika Nowis

The paper develops segmented polyA tail designs to improve DNA stability and mRNA translatability, finding that longer segmented tails significantly enhance protein production.

Cellohood identifies cellular neighborhoods in spatial transcriptomics data, revealing clinically relevant patterns across multiple granularity levels.

This study shows renal cancer cells secrete amphiregulin, recruiting MSCs and inducing their glycolytic switch, which supports tumour growth.

This paper introduces a chemical method to circularize in vitro transcribed RNA, producing chemically circularized RNAs (chem-circRNAs) with high efficiency and compatibility with modifications.

This study shows SARS-CoV-2 viroporins ORF3a, E, and M activate inflammasomes in macrophages and induce IL-1α release in pulmonary epithelial and endothelial cells, contributing to immunothrombosis in COVID-19.

This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.

Celloscope deconvolves cell types in spatial transcriptomics data using marker genes, outperforming existing methods and accurately identifying brain structures and immune infiltrates.