Chirlmin Joo

The paper introduces SPARXS-Hyb, a method for multiplexed screening of DNA hybridization kinetics, identifying sequences with improved performance in DNA-PAINT.

The paper identifies heparan sulfate (HS) as a key factor for cell-surface RNA (csRNA) presentation and reveals a ternary complex of HS, RNA, and RNA-binding proteins that recruits immune receptors.

The paper identifies potential ambiguities in glycoRNA analysis by showing that RNase sensitivity of glycosylated RNA species depends on purification methods, suggesting co-purification of non-glycoRNA glycoconjugates.

This study investigates DNA binding and diffusion on hBN surfaces, showing non-specific binding and confinement, and demonstrates potential for nanofluidic biomolecule manipulation.

The paper introduces iMAX FRET, a single-molecule method for structural analysis that captures 3D biomolecular structures and conformational changes through FRET and geometrical reconstruction.

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

The paper introduces a three-step point set registration method for aligning microscopy datasets, demonstrating its use in combining fluorescence and sequencing data.

This paper introduces a method to map amino acid positions and post-translational modifications in single protein molecules with sub-nanometer resolution using FRET-based single-molecule protein fingerprinting.

The paper develops a live-cell imaging assay to study how mRNA structures affect AGO2-siRNA interactions and mRNA degradation.

This study characterizes CbAgo, a mesophilic prokaryotic Argonaute that enables DNA-guided DNA cleavage at moderate temperatures using specific siDNA guides.