Author

Ding-Wen Chen

Children's Hospital of PhiladelphiaORCID 0000-0003-2806-0307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Deanne M. TayloriD· 2 shared Jian‐Meng Fan· 2 shared Julie M. Schrey· 2 shared Peter KurreiD· 2 shared Dana Venditti MitchelliD· 1 shared Empar Baltasar PéreziD· 1 shared Eric K. WafulaiD· 1 shared Martin P CarrolliD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Deanne M. TaylorORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer LettersPeer-reviewedFeb 26, 2025

Leukemia confers a durable imprint on healthy hematopoietic stem and progenitor cells

Ding-Wen Chen, Julie M. Schrey, Eric K. Wafula…·Peter Kurre

This study shows that healthy hematopoietic stem and progenitor cells (HSPCs) retain long-term transcriptomic and epigenetic changes after exposure to acute myeloid leukemia (AML) blasts, leading to enhanced inflammatory and metabolic responses upon secondary challenge.

DOI 10.1016/j.canlet.2025.217590

mousebulk RNA-seq

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Cancer BiologyLeukemiaPeer-reviewedJan 16, 2024

Inflammatory Recruitment of Healthy Hematopoietic Stem and Progenitor Cells in the Acute Myeloid Leukemia Niche

Ding-Wen Chen, Jian‐Meng Fan, Julie M. Schrey…·Peter Kurre

This study shows that healthy hematopoietic stem and progenitor cells (HSPCs) adopt inflammatory gene expression programs in the AML niche, driven by AML-derived extracellular vesicles.

37 citationstop 1%

mousescRNA-seq

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