Katharine C. Hsu

This study shows that engineered NKG2C+ NK-like T cells have better antitumor effects and lower cytokine release syndrome risk than conventional CAR-T and CAR-NK cells.

This study shows that interleukin-12 signaling integrates with antigen receptor signals in a context-dependent manner to determine the epigenetic and functional fate of cytotoxic lymphocytes.

This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.

The paper identifies CD8+ NK cells as a Mtb-responsive population with enhanced maturity and cytotoxicity in human TB infection, correlating with disease resistance.

The paper identifies a naive-memory relationship between CD56bright and adaptive human natural killer cells through phenotypic, transcriptional, and functional profiling.