Joseph Chai-Yuen Sun

Whole-exome sequencing of memory NK cells from 81 CMV-seropositive donors reveals dominant somatic clones, early-life origin, and positive selection, with Kmt2d loss shifting mouse NK fitness.

This study shows that interleukin-12 signaling integrates with antigen receptor signals in a context-dependent manner to determine the epigenetic and functional fate of cytotoxic lymphocytes.

The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.

This study shows STAT3 acts as an inflammation-dependent transcriptional switch in NK cells, regulating differentiation through MYB and BLIMP-1 under different inflammatory conditions.

The paper identifies an IFN-STAT1-CYBB axis that mediates protective crosstalk between plasmacytoid dendritic cells and neutrophils during Aspergillus fumigatus infection.

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

This study reveals that IL-21 regulates B cell fate through context-dependent effects on apoptosis and proliferation, using a conditional knock-out model and ex vivo cultures.

The paper identifies a naive-memory relationship between CD56bright and adaptive human natural killer cells through phenotypic, transcriptional, and functional profiling.

This study shows that RAG suppresses group 2 innate lymphoid cells (ILC2s), affecting their cytokine production and contributing to inflammation in atopic dermatitis.