Edward Fielder

The paper identifies SQ-1 as a small molecule that activates autophagy by promoting p62 oligomerisation, improving mitochondrial clearance and cell viability in NPC1 disease models.

The paper proposes a four-process model of ageing that connects DNA damage, metabolic slowdown, and cellular selection to explain age-related diseases and the evolutionary basis of ageing.

This study compares the anti-ageing effects of a multi-ingredient nutraceutical and a senolytic intervention in old mice, finding both extend lifespan similarly but differ in healthspan benefits.

This study shows that mild mitochondrial uncoupling enhances the senolytic effectiveness of BH3 mimetics in vitro and in vivo by targeting senescent cell vulnerabilities.

This paper connects metabolic slowdown to ageing and age-related diseases through a fuel and energy model, explaining anti-ageing interventions and paradoxes of ageing.