David R. Greaves

This study identifies Cn-alkylpyrones as endogenous agonists for GPR84, linking fatty acid biosynthesis derailment to pro-inflammatory signaling through KR inhibition.

The paper identifies ligands with varying steric profiles that exhibit different β-arrestin recruitment capacities at GPR84, revealing a mechanism for controlling signaling bias.

This study shows that high cholesterol induces epigenetic changes in hematopoietic stem cells that persist after cholesterol reduction, leading to systemic immunometabolic dysfunction.

This paper shows that inhibiting BTK in adipose tissue macrophages enhances OxPhos and shifts macrophages to an M2-like state, reducing inflammation and improving metabolic outcomes in obesity.

This study identifies two distinct adrenal macrophage subsets in mice and shows that foamy macrophages regulate corticosteroid production through cholesterol accumulation.

This study shows that tissue-resident macrophages are essential for lymphatic vessel growth and patterning during heart development by remodeling the vascular plexus.

This study shows that inhibiting BTK with ibrutinib reduces inflammation and prevents insulin resistance and microvascular disease in mice and human macrophages.