Christoph Thiemermann

The paper analyzes peptide-level evidence from proteomics datasets and finds a depletion of basic peptides in detected evidence compared to theoretical tryptic peptides.

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

This study shows artesunate reduces kidney fibrosis by restoring Klotho protein and inhibiting the Wnt/β-catenin pathway in both mouse and human models.

This paper shows that inhibiting BTK in adipose tissue macrophages enhances OxPhos and shifts macrophages to an M2-like state, reducing inflammation and improving metabolic outcomes in obesity.

This study shows that inhibiting BTK with ibrutinib reduces inflammation and prevents insulin resistance and microvascular disease in mice and human macrophages.