Author

Javier Marcelo Di Noia

Montreal Clinical Research InstituteORCID 0000-0003-2896-0321Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Poorani Ganesh SubramaniiD· 2 shared Aaron David SchimmeriD· 1 shared Alin VonicaiD· 1 shared Andrew Chatr‐aryamontriiD· 1 shared Anne Helness· 1 shared Brian T. WilhelmiD· 1 shared Christoph DieterichiD· 1 shared Corey NislowiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Poorani Ganesh SubramaniORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintAug 4, 2025

A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept

Andrew Chatr‐aryamontri, Li Zhang, Ndeye Khady Thiombane…·Thierry Bertomeu

The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.

DOI 10.1101/2025.08.04.665369

humanCRISPR screen

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ImmunologyEMBO ReportsPeer-reviewedMay 14, 2024

A conserved role of hnRNPL in regulating alternative splicing of transcriptional regulators necessary for B cell activation

Poorani Ganesh Subramani, Jennifer Fraszczak, Anne Helness…·Javier Marcelo Di Noia

This study shows hnRNPL regulates alternative splicing of transcriptional regulators in B cells, essential for activation and antibody responses.

22 citations

mousebulk RNA-seq

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Molecular BiologybioRxivPreprintJul 29, 2020

APOBEC2 is a Transcriptional Repressor 1 required for proper Myoblast Differentiation

Jose Paulo Lorenzo, Linda Molla, Ignacio L. Ibarra…·Fotini Nina Papavasiliou

This study identifies APOBEC2 as a transcriptional repressor that represses non-myogenesis pathway genes to facilitate proper myoblast differentiation.

4 citations

mouseDNA methylation

𝕏 PostBluesky