Thierry Bertomeu

This study shows that mitochondrial ETF insufficiency promotes cancer growth by reprogramming bioenergetics and signaling pathways in neoplastic cells.

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

The paper identifies PRR14L as a gene affecting mitotic fidelity and sensitivity to MPS1 inhibition through a CRISPR/Cas9 screen and proximity labeling.

The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.

This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.

This paper identifies ATP5I as a target of metformin, showing its role in mediating metabolic and antiproliferative effects through mitochondrial dysfunction and altered ATP synthase oligomerization.

The paper demonstrates that viral-induced hypomorphs of GBF1 can be targeted using synthetic lethality to selectively kill virus-infected cells.

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.

The paper identifies 2,280 essential genes in human B-cell lymphoma cells using an EKO library and RANKS tool, revealing context-specific essentiality and evolutionary patterns.