Martin Böttcher

The paper identifies an EBV-specific T cell program in MS patients that contributes to CNS autoimmunity through B cell and myeloid cell activation.

The paper identifies a fibroblast-IL-7 feedback loop that promotes immunosuppressive monocyte-derived cells, which restrain CD4+ T cell responses during infection.

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.

This study investigates how kinase inhibitors reshape the immunopeptidome in CML by altering HLA-I peptide presentation through three molecular mechanisms.

This study identifies CD36 as a metabolic checkpoint sustaining Th2 cell tissue residency in allergic asthma by regulating GATA3 and PPARγ expression and interactions with dendritic cells.

This study identifies xCT regulation pathways in colon cancer using patient-specific models and reveals potential therapeutic targets for chemotherapy resistance.

The paper identifies BCR::ABL1-independent survival mechanisms in CML using phosphoproteomics and computational analysis, highlighting FLT3 as a therapeutic target for TKI-resistant cases.

This study develops a systems-based strategy to predict drug sensitivity in FLT3-ITD AML by integrating genomic, transcriptomic data with a prior-knowledge signaling network.