Michael G. Sacher

This study re-examines the role of TANGO2 homologs in C. elegans and finds that phenotypes previously linked to heme transport may instead reflect mitochondrial dysfunction and oxidative stress.

This study develops a humanized yeast model to study TRAPP complex mutations, showing that human TRAPPC1 variants cause secretion and autophagy defects in yeast, mirroring human fibroblast defects.

This study identifies lipid imbalances in TANGO2-deficient human cells and shows vitamin B5 supplementation rescues these imbalances, suggesting a role for TANGO2 in lipid metabolism.

This study identifies KLHL40 as a negative regulator of ER-Golgi trafficking through ubiquitylation, revealing its role in skeletal muscle development and disease.