Rohit A Gupta

This paper introduces a bioelectronic implant for recording neural activity in the distal colon of freely-moving rats, demonstrating its ability to capture electrophysiological responses and colonic activity related to food intake and stress.

This paper identifies GPR35 as a target for non-opioid analgesics by showing it inhibits TRPA1-mediated colonic hypersensitivity through suppression of Substance P release.

This study identifies Angiotensin II as a pro-nociceptive mediator in IBD by showing increased Agt expression and AT1 receptor activation in colonic neurons.

The paper shows that KV7 channel openers, but not SK/IK channel openers, reduce colonic afferent responses to noxious stimuli, suggesting KV7 channels as potential targets for abdominal pain treatment.