Irena Levitan

This study identifies KCNMB1 and potassium efflux as regulators of cellular stiffness in cancer cells, showing that BK channel activation reduces metastasis and enhances immune cell cytotoxicity.

This study shows that a single-point mutation in Kir2.1 channels protects mice from diet-induced obesity by altering fat distribution and increasing energy expenditure.

This study shows Kir2.1 channels link flow-induced signaling to Piezo1/PI3K/Akt1 pathways, restoring flow-induced vasodilation in Kir2.1-deficient endothelium.

This study shows that CD36-mediated lipid uptake causes endothelial stiffening, leading to barrier disruption and atherosclerosis in mouse models, with sex-dependent effects.

This study identifies a TRPC6 mutation that protects mice from acute lung injury by promoting endothelial regeneration and preventing vascular injury.