Author

Mike A. Osta

American University of BeirutORCID 0000-0003-3078-6190Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:Drosophila· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Sally A. SaabiD· 3 shared Bianca MorejóniD· 2 shared Kristin MicheliD· 2 shared Suheir Zeineddine· 2 shared Caterina ScoglioiD· 1 shared Christopher T. CulbertsoniD· 1 shared Chunju AniD· 1 shared Eve C. Metto· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

Sally A. SaabORCID

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3 papers

Recent·Most cited

MicrobiologyFrontiers in Cellular and Infection MicrobiologyPeer-reviewedAug 1, 2024

Late sporogonic stages of Plasmodium parasites are susceptible to the melanization response in Anopheles gambiae mosquitoes

Suheir Zeineddine, Sana Jaber, Sally A. Saab…·Mike A. Osta

This study shows that late-stage Plasmodium parasites in mosquitoes are susceptible to melanization, with distinct immune regulation for different stages.

9 citations

mousehuman

𝕏 PostBluesky

ImmunologyMicrobes and InfectionPeer-reviewedNov 1, 2023

Insight into the structural hierarchy of the protease cascade that regulates the mosquito melanization response

Sally A. Saab, Xiufeng Zhang, Suheir Zeineddine…·Mike A. Osta

The paper defines the structural hierarchy of An. gambiae cSPs in the melanization cascade and shows their functional interactions with cSPHs.

16 citations

proteomicsexperimental assay

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ImmunologyJournal of Innate ImmunityPeer-reviewedJan 1, 2023

CLIPB4 is a central node in the protease network that regulates humoral immunity in Anopheles gambiae mosquitoes

Xiufeng Zhang, Shasha Zhang, Junyao Kuang…·Kristin Michel

The paper identifies CLIPB4 as a central protease in the immune network of Anopheles gambiae, showing its role in melanization and antibacterial immunity through interactions with SRPN2.

16 citations

Drosophilaproteomics

𝕏 PostBluesky