Kezhang He

This paper identifies a drug combination that irreversibly senesces drug-tolerant persister cells, preventing tumor relapse in melanoma models.

This study identifies reinforced cell identity as a driver of cancer development and demonstrates a drug targeting this identity in AML.

This study identifies a unique mechanism by which SSX1 recognizes H2AK119Ub nucleosomes through a cryptic groove, enabling specific hijacking of the BAF complex in synovial sarcoma.

This study shows that a two-drug combination induces regenerative cardiac cells from cardiomyocytes in vitro and in vivo, improving heart function after injury.