Jiangbin Wu

This paper introduces 3D-VirtualCM, a method to reconstruct full cardiomyocyte transcriptomes from spatial transcriptomic sections, revealing spatial and transcriptional heterogeneity in infarcted mouse hearts.

This study shows that loss of EPRS1 in cardiomyocytes causes dilated cardiomyopathy and heart failure, with altered protein homeostasis and metabolic pathways.

The paper identifies dsRNA structures in uORFs that regulate translation and shows ASO targeting can modulate mORF translation and reduce cardiac hypertrophy.

This study identifies PRRC2B as an RNA binding protein that regulates translation of specific mRNAs, including cell cycle regulators, and inhibits cell proliferation by affecting G1/S phase transition.

This study shows that elevated ENO2 disrupts autophagy in vascular smooth muscle cells, contributing to aortic dissection development.