Alexander D. Borowsky

This study shows that the p95 isoform of HER2 promotes metastasis by biasing MRTFA-dependent signaling through specific tyrosine phosphorylation.

This study shows that cancer progression is nonlinear, with a critical occult transition leading to lethal tumors before detection, challenging the linear model of cancer growth.

This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.

This study identifies immune microenvironment features and myoepithelial continuity as key determinants of progression in high-risk DCIS.

This study identifies how changes in epithelial proportions and transcriptional states influenced by pregnancy and BMI affect hormone signaling and breast cancer risk in premenopausal women.

The paper creates a breast pre-cancer atlas by analyzing multiple micro-dissected regions from DCIS cases, revealing molecular and micro-environmental diversity and immune states associated with progression risk.

This paper develops a method to improve mutational profiling of pre-malignant lesions using degraded FFPE DNA, achieving better coverage and variant calling accuracy.