Author

Jane Chen

University of California, IrvinePrimary ORCID profile (0000-0002-3986-8785 · 7 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jane CheniD7 papers · Howard Hughes Medical Institute

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alejandra V. PatinoiD· 1 shared Alexander D. BorowskyiD· 1 shared Angela G. FleischmaniD· 1 shared Brianna HooveriD· 1 shared Eli M. SoyferiD· 1 shared Eshika Arora· 1 shared Helen Q. Huang· 1 shared Hew Yeng LaiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alejandra V. PatinoORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 30, 2025

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

William Lucas P Wadley, Helen Q. Huang, Hew Yeng Lai…·Angela G. Fleischman

This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.

DOI 10.1101/2025.09.30.679613

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 2, 2025

Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.

Hyeongsun Moon, Hidetoshi Mori, Jane Chen…·Alexander D. Borowsky

This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.

DOI 10.1101/2025.02.02.636128

mousebulk RNA-seq

𝕏 PostBluesky