Author

Madison B. Adolph

Vanderbilt UniversityORCID 0000-0002-4761-7388Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

David CorteziD· 2 shared Swati BalakrishnaniD· 2 shared Walter ChaziniD· 2 shared Atharv S. GarjeiD· 1 shared Atika MaliqueiD· 1 shared Barbara Teodoro-Castro· 1 shared Elena V. ShashkovaiD· 1 shared Florian MoratiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

David CortezORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 28, 2026

STING causes replication stress and nascent DNA degradation via SAMHD1

Barbara Teodoro-Castro, Rafael Cançado de Faria, Elena V. Shashkova…·Susana Gonzalo

This study shows STING causes replication stress and nascent DNA degradation via SAMHD1 in progeria and tumor cells, revealing a STING-SAMHD1 axis that drives genome instability.

1 citation

humanDNA methylation

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedMar 11, 2024

Structure of RADX and mechanism for regulation of RAD51 nucleofilaments

Swati Balakrishnan, Madison B. Adolph, Miaw-Sheue Tsai…·Walter Chazin

This paper investigates the structure and mechanism of RADX, a negative regulator of RAD51 nucleofilaments, showing it caps and restricts RAD51 filament growth to regulate replication fork reversal.

5 citations

structural biologyexperimental assay

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Molecular BiologyJournal of Molecular BiologyPeer-reviewedOct 1, 2023

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activity

Madison B. Adolph, Atharv S. Garje, Swati Balakrishnan…·David Cortez

The paper identifies RADX separation of function mutants using CRISPR base editing screens, showing reduced RAD51 ATP hydrolysis activity and replication defects.

4 citations

experimental assay

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