Author

Nathaniel Jillette

The Jackson Laboratory for Genomic MedicineORCID 0000-0003-3328-4401Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Albert W. ChengiD· 3 shared Aziz TaghbaloutiD· 3 shared Menghan Du· 2 shared Sheng LiiD· 2 shared Wojciech RosikiewicziD· 2 shared Aaron Michael TayloriD· 1 shared Abhijit RathiD· 1 shared Adam D. LindsayiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenomics

Albert W. ChengORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologyCancersPeer-reviewedJun 24, 2025

Immunosuppressive tumor microenvironment of osteosarcoma

Aaron Michael Taylor, Jianting Sheng, Patrick Kwok Shing Ng…·Ching C. Lau

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

39 citationstop 1%

humanscRNA-seq

𝕏 PostBluesky

GenomicsNature CommunicationsPeer-reviewedApr 6, 2022

CRISPR-mediated Multiplexed Live Cell Imaging of Nonrepetitive Genomic Loci

Patricia A. Clow, Menghan Du, Nathaniel Jillette…·Albert W. Cheng

This paper introduces a CRISPR-based imaging method to label nonrepetitive genomic loci and track chromatin dynamics in live cells.

93 citationstop 2%

imagingexperimental assay

𝕏 PostBluesky

BioinformaticsGenome biologyPeer-reviewedOct 18, 2021

DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluation

Yang Liu, Wojciech Rosikiewicz, Ziwei Pan…·Sheng Li

The paper evaluates DNA methylation calling tools for Oxford Nanopore sequencing using human data and provides an online database for comparing tool performance.

243 citationstop 1%

humanlong-read sequencing

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GenomicsNature CommunicationsPeer-reviewedSep 20, 2019

Casilio-ME: Enhanced CRISPR-based DNA demethylation by RNA-guided coupling methylcytosine oxidation and DNA repair pathways

Aziz Taghbalout, Menghan Du, Nathaniel Jillette…·Albert W. Cheng

Casilio-ME enhances CRISPR-based DNA demethylation by coupling TET1 with DNA repair factors to activate methylation-silenced genes.

53 citations

DNA methylationexperimental assay

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