Author

Tim Aguirre

Humboldt-Universität zu BerlinORCID 0000-0003-3344-5877Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anja SchütziD· 1 shared Carola Seyffarth· 1 shared Dorothea FiedleriD· 1 shared Gillian L. DornaniD· 1 shared Jens Peter von KriesiD· 1 shared Martin NeuenschwanderiD· 1 shared Sarah HostachyiD· 1 shared Volker HauckeiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

Anja SchützORCID

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1 paper

Recent·Most cited

BiochemistryeLifePeer-reviewedJun 23, 2023

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

Tim Aguirre, Gillian L. Dornan, Sarah Hostachy…·Dorothea Fiedler

The paper identifies FMP-201300 as a potent and selective inhibitor for IP6K1 and IP6K2 with a valine gatekeeper mutation, revealing an allosteric mechanism of action.

6 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky